Tha Kaek doesn't have an airport with regularly scheduled flights, so the only way to get there is by bus or private car transfer.
The main bus station at Tha Kaek
Buses to and from Tha Kaek are available from all the nearby provinces, such as Savanakhet and Pakse, as well as Vientiane. There is also an international bus service connecting Tha Kaek to Nakhon Phanom in Thailand across the new Friendship Bridge 3, opened in 2011. The trip takes about 90 minutes, of which more than a third is usually taken up by immigration formalities. This makes Nakhon Phanom the closest airport to Tha Kaek
The bus station is a few kilometers from the riverside old town area where you'll most likely be staying. You can usually share a tuk-tuk into town if enough people are going, but if there's nobody else going that way, you may pay 40,000 to 50,000 Kip (4.80 USD to 6.00 USD) for the ride.